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Automated screening for mutants affecting dopaminergic-neuron
specification in C. elegans
Doitsidou, M., Flames, N., Lee, A.C., Boyanov, A. & Hobert, O.
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W. 168th Street, New York, New York 10032, USA
Nature Methods 5, 869 - 872 (2008)
Published online: 31 August 2008 | doi:10.1038/nmeth.1250
• View Abstract
Commentary: Classical genetics goes high-tech
David S Fay
doi:10.1038/nmeth1008-863
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Anti-Fungal Innate Immunity in C. elegans Is Enhanced by Evolutionary Diversification of Antimicrobial Peptides
Nathalie Pujol
1,
2,
3,
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Olivier Zugasti
1,
2,
3,
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Daniel Wong
1,
2,
3
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Carole Couillault
1,
2,
3,
C. Léopold Kurz
1,
2,
3,
Hinrich Schulenburg
4,
Jonathan J. Ewbank
1,
2,
3,
*
1 Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, Marseille, France 2 INSERM, U631, Marseille, France 3 CNRS, UMR6102, Marseille, France 4 Department of Animal Evolutionary Ecology, Zoological Institute, University of Tuebingen, Tuebingen, Germany
PLoS Pathogens 4(7): e1000105 doi:10.1371/journal.ppat.1000105.
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Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis.
Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, Jin Y, Chisholm AD, Ewbank JJ.
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, 13288 Marseille cedex 9, France.
Curr Biol. 2008 Apr 8;18(7):481-489.
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Effects of Genetic Mutations and Chemical Exposures on Caenorhabditis elegans Feeding: Evaluation of a Novel, High-Throughput Screening Assay
Windy A. Boyd1,
Sandra J. McBride2,
Jonathan H. Freedman1,
2
*
1 Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America 2 Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, United States of America
PLoS ONE 2(12): e1259 doi:10.1371/journal.pone.0001259
Abstract
Government agencies have defined a need to reduce, refine or replace current mammalian-based bioassays with testing methods that use alternative species. Invertebrate species, such as Caenorhabditis elegans, provide an attractive option because of their short life cycles, inexpensive maintenance, and high degree of evolutionary conservation with higher eukaryotes. The C. elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative.
Here a high-throughput assay is described that uses flow cytometry to measure C. elegans feeding by determining the size and intestinal fluorescence of hundreds of nematodes after exposure to fluorescent-labeled microspheres. . . .
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A global analysis of genetic interactions in Caenorhabditis elegans
Alexandra B Byrne*†, Matthew T Weirauch‡, Victoria Wong*, Martina Koeva‡, Scott J Dixon*†, Joshua M Stuart‡ and Peter J Roy*
Addresses: *Department of Medical Genetics and Microbiology, The Terrence Donnelly Centre for Cellular and Biomolecular Research, 160 College St, University of Toronto, Toronto, ON, M5S 3E1, Canada. †Collaborative Program in Developmental Biology, University of Toronto, Toronto, ON, M5S 3E1, Canada. ‡Department of Biomolecular Engineering, 1156 High Street, Mail Stop SOE2, University of California, Santa Cruz, CA 95064, USA.
Correspondence: Peter J Roy. Email: peter.roy@utoronto.ca; Joshua M Stuart. Email: jstuart@soe.ucsc.edu
Journal of Biology, 2007, 6:8
Published 26 September, 2007
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Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans.
Denis Dupuy1,10, Nicolas Bertin1,2,10,
César A Hidalgo1,3,10, Kavitha Venkatesan1, Domena Tu4,
David Lee4, Jennifer Rosenberg1, Nenad Svrzikapa1, Aurélie Blanc1,
Alain Carnec1, Anne-Ruxandra Carvunis1, Rock Pulak5, Jane Shingles6,
John Reece-Hoyes6, Rebecca Hunt-Newbury7, Ryan Viveiros7, William A Mohler8,
Murat Tasan9, Frederick P Roth9, Christian Le Peuch2, Ian A Hope6,
Robert Johnsen4, Donald G Moerman7, Albert-László Barabási1,3,
David Baillie4 & Marc Vidal1
1Center for Cancer Systems Biology (CCSB), and Department of Cancer Biology, Dana-Farber Cancer Institute and
Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.
2Centre de Recherche en Biochimie Macromole´culaire, Centre National de la Recherche Scientifique FRE 2593,
1919 Route de Mende, 34293 Montpellier Cedex 5, France.
3Center for Complex Network Research, Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall,
Notre Dame, Indiana 46556, USA. 4Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University
Drive, Burnaby, British Columbia V5A 1S6, Canada.
5Union Biometrica, 84 October Hill Road, Holliston, Massachusetts 01746, USA.
6Institute of Integrative and Comparative Biology, University of Leeds, Clarendon Way, Leeds LS2 9JT, West
Yorkshire, UK.
7Department of Zoology, The University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia
V6T 1Z4, Canada.
8Department of Genetics and Developmental Biology and Center for Cell Analysis and Modeling, University of
Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA.
9Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, and Department of Biological Chemistry
and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
10These authors contributed equally to this work. Correspondence should be addressed to M.V. (marc_vidal@dfci.harvard.edu), D.B. (baillie@sfu.ca) or A.-L.B. (alb@nd.edu).
Nature Biotechnology 25, 663 - 668 (2007)
Published online: 7 May 2007
•
doi:10.1038/nbt1305
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16th International C. elegans Conference 2007 June 27 - 30 |
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Click on the titles of the following posters to view an abstract:
Genome-scale analysis of in vivo spatiotemporal promoter activity in C. elegans.
Denis Dupuy, Nicolas Bertin, César Hidalgo, Kavitha Venkatesan, Domena Tu, David Lee, Nenad Svrzikapa, Anne-Ruxandra Carvunis, Rock Pulak, Ian Hope, John Reece-Hoyes, Rebecca Hunt-Newbury, Ryan Viveiros, William Mohler, Murat Tasan, Frederick Roth, Donald Moerman, Albert-László Barabási, David Baillie, Marc Vidal.
Genetic dissection of the transcriptional response to wounding and fungal infection.
Nathalie Pujol, C. Leopold Kurz, Sophie Cypowyj, Daniel Wong, Andrew Chisholm, Jonathan Ewbank.
A high throughput screen for novel anti-infective compounds.
Terence I. Moy, Annie L. Conery, Anne E. Carpenter, Anthony R. Ball, Kim Lewis, Frederick M. Ausubel.
Characterization of the role of peni( fr8) in innate immunity against fungal infection.
Kwang-Zin Lee, Nathalie Pujol, Andrew Chisholm, Jonathan Ewbank.
Automated drug screening and chemical genetics in C. elegans models of rare diseases.
Jean Giacomotto, Maité Carre-Pierrat, Laurent Segalat.
Isolation and characterization of C. elegans mutants deficient in PMK-1-dependent immunity.
Robert Shivers, Tristan Kooistra, Bethany Redding, Dennis H. Kim.
A Sodium: Neurotransmitter symporter Family protein required for the induction of antimicrobial peptides in C. elegans.
Katja Ziegler, Jonathan Ewbank, Nathalie Pujol.
High-throughput chemical screening using C. elegans growth and development.
Windy A. Boyd, Sandra J. McBride, Marjolein V. Smith, Grace E. Kissling, Julie R. Rice, Daniel W. Snyder, Christopher J. Portier, Jonathan H. Freedman.
Using a C. elegans feeding response assay in high-throughput chemical and genetic screening.
Windy A. Boyd, Sandra J. McBride, Jonathan H. Freedman.
Genetic dissection of Spinal Muscular Atrophy in Drosophila and C. elegans.
Jevede D. Harris, Tom Barsby, Amy K. Walker, Anne C. Hart. Gelsomino, Paolo Bazzicalupo.
Large scale genetic screens for cell fate mutants using worm sorter technology.
Vincent Bertrand, Nuria Flames, Maria Doitsidou, Richard Poole, Janine Recio, Oliver Hobert.
Semi-automated genetic screen for temperature sensitive mutations that abolish the early embryonic expression of the hox gene ceh-13.
Stephan Knierer, Adrian Streit.
The C. elegans dysferlin homolog fer-1 is expressed in muscle.
Todd Lamitina, Olga Lozynska, Tejvir Khurana.
Toward the development of a database for the storage and integration of COPAS™ BioSorter™ data.
Lisa R. Matthews, Philippe Vaglio, Jonathan Ewbank.
A French functional genomics platform.
Yohann Duverger, Sarah Scaglione, Daniel Wong, Jérôme Reboul, Jonathan Ewbank.
A semi-automated high-throughput approach to the generation of transposon insertion mutants.
Yohann Duverger, Jérôme Belougne, Sarah Scaglione, Dominique Brandli, Christophe Beclin, Jonathan Ewbank. |
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A semi-automated high-throughput approach to the generation of transposon insertion mutants in the nematode Caenorhabditis elegans
Yohann Duverger1,2,3, Jérôme Belougne4, Sarah Scaglione1,2,3, Dominique Brandli4, Christophe Beclin4 and Jonathan J. Ewbank 1,2,3*
1Centre d’Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, 13288 Marseille cedex 9, France, 2INSERM, U631, 13288 Marseille, France, 3CNRS, UMR6102, 13288 Marseille, France and 4CNRS, Institut de Biologie du Développement de Marseille-Luminy, Marseille, France
Received September 5, 2006; Revised October 18, 2006; Accepted November 3, 2006
Nucleic Acids Research, 2006, Vol. 00, No. 00 e1–8
• DOI:10.1093/nar/gkl1046
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Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo
Hidehito Kuroyanagi1,2, Tetsuo Kobayashi3,4, Shohei Mitani3,4, & Masatoshi Hagiwara1,2
1School of Biomedical Science and 2Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. 3Department of Physiology, Tokyo Women’s Medical University School of Medicine, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. 4CREST, JST, Hon-cho, Kawaguchi, Saitama 332-0012, Japan.
Nature Methods 3, 909 - 915 (01 Nov 2006) Article
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A small-molecule screen in C. elegans yields a new calcium channel antagonist.
Kwok TC, Ricker N, Fraser R, Chan AW, Burns A, Stanley EF, McCourt P,
Cutler SR, Roy PJ.
Department of Medical Genetics and Microbiology, and The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Nature. 2006 May 4;441(7089):91-5.
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Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression.
Lamitina T, Huang CG, Strange K.
Departments of Anesthesiology and Pharmacology, Vanderbilt University, T4208 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232.
The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic homeostasis. The signals and signaling mechanisms that regulate osmoprotective gene expression in animal cells are poorly understood. Here, we show that gpdh-1 and gpdh-2, genes that mediate the accumulation of the organic osmolyte glycerol, are essential for survival of the nematode Caenorhabditis elegans during osmotic stress. Expression of GFP driven by the gpdh-1 promoter (Pgpdh-1::GFP) is detected only during hypertonic stress but is not induced by other stressors. Using Pgpdh-1::GFP expression as a phenotype, we screened approximately 16,000 genes by RNAi feeding and identified 122 that cause constitutive activation of gpdh-1 expression and glycerol accumulation. Many of these genes function to regulate protein translation and cotranslational protein folding and to target and degrade denatured proteins, suggesting that the accumulation of misfolded proteins functions as a signal to activate osmoprotective gene expression and organic osmolyte accumulation in animal cells. Consistent with this hypothesis, 73% of these protein-homeostasis genes have been shown to slow age-dependent protein aggregation in C. elegans. Because diverse environmental stressors and numerous disease states result in protein misfolding, mechanisms must exist that discriminate between osmotically induced and other forms of stress-induced protein damage. Our findings provide a foundation for understanding how these damage-selectivity mechanisms function.
• PMID: 16880390 [PubMed - as supplied by publisher]
• Proc Natl Acad Sci U S A.
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Nature Genetics Vol. 37, pgs. 894 - 898 (2005), “A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.”
Shane L Rea1,4, Deqing Wu1,4, James R Cypser1, James W Vaupel2 & Thomas E Johnson1,3
1) Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, Colorado 80309, USA.
2) Max Planck Institute for Demographic Research, Konrad-Zuse-Strasse 1, D-18057, Rostock, Germany.
3) Department of Integrative Biology, University of Colorado at Boulder, Box 447, Boulder, Colorado 80309, USA.
4) These authors contributed equally to this work.
Published online: 24 July 2005.
• DOI:10.1038/ng1608
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15th International C. elegans Meeting 2005, June 25 – 29 |
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A non-biased, in vivo genetic screen for genes that protect against necrosis.
(Poster 758A)
Wenying Zhang, Monica Driscoll. Dept Mol Biol & Biochem, Rutgers Univ, Piscataway, NJ.
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Multi-parameter axial profiling of transgenic C. elegans expressing fluorescent proteins from various cell-specific, tissue specific and developmentally regulated promoters. (Poster 1172A)
Bo Wang1, Julia Thompson1, Yanping Zhang2, Michael Herman2, Mariya Lomakina1, Bruce Holcombe1, Rock Pulak1.
1) Union Biometrica, Holliston, MA;
2) Division of Biology, Kansas State University, Manhattan, Kansas.
• View Abstract
A French functional genomics platform. (Poster 1294C)
Aurélie Blanc1, Yohann Duverger1 Jérôme Reboul2, Daniel Wong1, Jonathan Ewbank1.
1) Centre d’Immunologie de Marseille-Luminy, INSERM/CNRS/Université de la Méditerranée, Marseille, France;
2) INSERM UMR 599, Institut Paoli Calmette, Marseille, France.
• View Abstract
The C. elegans Localizome Project: a beginning. (Plenary Session 212)
Denis Dupuy1, Nicolas Bertin1, Qianru Li1, Alain Carnec1, Jennifer Rosenberg1, Rock Pulak2, Jane Shingles3, John Reece-Hoyes3, Domena Tu4, David Lee4, Rebecca Newbury5, Ryan Viveiros5, William A. Mohler6, Ian A. Hope3, Don Moerman5, Robert Johnsen4, David Baillie4, Marc Vidal1.
1) Center for Cancer Systems Biology (CCSB)/Dana-Farber Cancer Institute/Harvard Medical school, Boston, MA;
2) Union Biometrica, Holliston, MA;
3) University of Leeds, Leeds, UK;
4) Department Molecular Biology and Biochemistry, Simon Fraser University,
Vancouver, BC;
5) Department of Zoology, The University of British Columbia, BC;
6) Dept. of Genetics and Developmental Biology University of Connecticut Health Center, Farmington, CT.
• View Abstract
Identification of new innate immunity genes. (Parallel Session 294)
Anne Millet, Nathalie Pujol, Jonathan Ewbank. Centre d’Immunologie de Marseille-Luminy, INSERM/CNRS/Univ. de la Méditerranée, Marseille, France.
• View Abstract
Stochastic Effects Make a Big Difference in How Long You Will Live
(If You Are a Worm). (Plenary session 311)
Thomas E. Johnson, Shane Rea, Deqing Wu, Jim Cypser. Inst Behavioral Genetics,
University of Colorado, Boulder, CO.
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A novel method of quantifying C. elegans feeding. (Poster 408B)
Windy A. Boyd, Sandra J. McBride, Jonathan H. Freedman. Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC.
• View Abstract
Development of medium-throughput toxicity screens using C. elegans. (Poster 409C)
Windy A. Boyd, Sandra J. McBride, Jonathan H. Freedman. Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC.
• View Abstract
Studies of Interactions between PAR Proteins. (Poster 1105C)
Jin Li1, Tak-Jun Hung2, Donato Aceto1, Shinya Aono3, Melissa Beers1,
Kenneth J Kemphues1.
1) Dept Molecular Biol & Genetics, Cornell Univ, Ithaca, NY;
2) Union Biometrica, Holliston, MA;
3) Department of Morphoregulaltion, Institute for Frontier Medical Sciences, Kyoto Univ, Kyoto, Japan.
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Experimental Biology 2005, April 2 - 6, 2005 |
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Genetic analysis of osmotically regulated gene expression in C. elegans
S. Todd Lamitina, Kevin Strange. Department of Anesthesiology, Vanderbilt University, 1161 21st Avenue South, MCN T4208, Nashville, TN, 37232.
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Developmental Biology, Volume 278, Issue 1, Pages 49- 59 "XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans"
H. Carlos Cardosoa, Carole Couillaultb, Cecile Mignon-Ravixa, Anne Milletb, Jonathan J. Ewbankb, Michel Fonte´sa, Nathalie Pujolb,*
aINSERM U491, Faculte´ de Me´decine la Timone, 27, Bd Jean Moulin, 13385 Marseille Cedex 5, France
bCentre d'Immunologie de Marseille Luminy, INSERM/CNRS/Universite´ de la Me´diterrane´e, Campus Luminy Case 906, 13288 Marseille Cedex 9, France.
Published 1 February 2005. doi:10.1016/j.ydbio.2004.10.014
• DOI:10.1016/j.ydbio.2004.10.014
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BMC Evolutionary Biology, 4:49 "Diversity and specificity in the interaction between Caenorhabditis elegans and the pathogen Serratia marcescens"
Hinrich Schulenburg*1 and Jonathan J Ewbank2, 1) Department of Evolutionary Biology, Institute for Animal Evolution and Ecology, Westphalian Wilhelms-University, Hüfferstr. 1, 48149 Münster, Germany and 2) Centre d'Immunologie de Marseille Luminy, INSERM/CNRS/Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France.
Published: 22 November 2004. doi:10.1186/1471-2148-4-49
• DOI:10.1186/1471-2148-4-49
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Journal of Lipid Research, Volume 45 (2004) "Long-term effects of sterol depletion in C. elegans: Sterol content of synchronized wild-type and mutant populations."
Mark Merris*, Jessica Kraeft*, G. S. Tint†.§ and John Lenard1*
*Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854
†Department of Veterans Affairs New Jersey Health Care System, 385 Tremont Avenue, East Orange, NJ 07018
§Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07101
• DOI: 10.1194/jlr.M400100-JLR200
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SETAC (Soc. of Environmental Toxicology & Chemistry) 2004, Nov 14-18, 2004 |
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High-throughput sublethal toxicity tests using the nematode
Caenorhabditis elegans.
Boyd, Windy1, McBride, Sandra1, Rice, Julie1, Freedman, Jonathan1,
1) Duke University, Durham, NC, USA
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Mechanisms of Ageing and Development, "Automated assays to study
longevity in C. elegans"
Maren Hertweck(1), and Ralf Baumeister, Bio3/Bioinformatics and Molecular Genetics,
Albert-Ludwigs University of Freiburg, Schänzlestr. 1, D-79104 Freiburg, Germany.
Published online: 20 October 2004
• DOI:10.1016/j.mad.2004.09.010 10.1038/ni1060
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DukeEnvironment Magazine, Fall 2004 "An Unlikely Star of Science: Jonathan Freedman Looks to Microscopic Roundworms to Document the Effects of Toxic Chemicals."
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Chapter 4: Practical applications of RNAi in C. elegans, "RNA interference: From Basic Biology to Drug Development," Stephens, K.E., O. Zugasti, N.J. O'Neil, P.E. Kuwabara. Cambridge University Press. Discusses the use of the COPAS BIOSORT to score
RNAi phenotypes complete with illustrations and pictures. SUMMER, 2004 |
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Nature Immunology 5, 488 - 494 (2004), "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM," Carole Couillault1, Nathalie Pujol1, Jérôme
Reboul2, Laurence Sabatier3, Jean-François Guichou4, Yuji Kohara5 &
Jonathan J Ewbank1
1) Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique/Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France. 2) Institut National de la Santé et de la Recherche Médicale U119, Institut Paoli Calmette, 13009 Marseille, France. 3) Institut de Biologie Moléculaire et Cellulaire, UPR 9022, Centre National de la Recherche Scientifique, 15 rue Descartes, 67084 Strasbourg Cedex, France. 4) Centre de Biochimie Structurale, Centre National de la Recherche Scientifique UMR 5048, Institut National de la Santé et de la Recherche Médicale UMR 554, Université de Montpellier 1, 29, rue de Navacelles, 34090 Montpellier Cedex, France. 5) National Institute of Genetics, Mishima 411, Japan.
Published online: 28 March 2004
• DOI:10.1038/ni1060
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Model Organisms in Drug Discovery (2003), "Chapter 3: Caenorhabditis Elegans Functional Genomics in Drug Discovery: Expanding Paradigms."
Chapter Authors: Titus Kaletta, Lynn Butler, Thierry Bogaert
Devgen NV, Technologiepark 9, B-9052 Ghent-Zwijnaarde, Belgium
Book Editor(s): Pamela M. Carroll, Kevin Fitzgerald Copyright ? 2003 John Wiley & Sons, Ltd
Published Online: 05 Jan 2005
Print ISBN: 0470848936 Online ISBN: 0470014067
• DOI: 10.1002/0470014067.ch3
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Nature Reviews Genetics 4, 380 -390 (2003), "Caenorhabditis elegans: an emerging genetic model for the study of innate immunity"
C. Léopold Kurz and Jonathan J. Ewbank, Centre d'Immunologie de Marseille Luminy, INSERM/CNRS/Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France.
• DOI:10.1038/nrg1067
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Med Sci (Paris) 19, 1209-17 (2003), [A worm's life]
Pujol, N. and Ewbank, J.J., Centre d'Immunologie de Marseille Luminy, Cnrs UMR 6102, Inserm U. 136, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 09, France.
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Free Radical Biology & Medicine, "An Automationed High-Throughput Assay for Survival of the Nematode Caenorhabditis elegans." Vol. 35, No. 6, pp. 558-565.
Matthew S. Gill, Anders Olsen, James N. Sampayo, and Gordon J. Lithgow, Buck Institute, Novato, CA (USA). PII: S0891-5849(03)00328-9. SEPTEMBER, 2003
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Lunch Seminar at Drug Discovery Technology Conference, August 11-13, 2003
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Use of the COPAS Biosort in a hi-throughput screen for genes that regulate lifespan.
Douglas Crawford and Cynthia Kenyon, Department of Biochemistry and Biophysics, University of California, San Francisco.
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West Coast C. elegans Meeting, August 10 - 13, 2002
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GFP screens for regulators of motor neuron differentiation, #242.
Joseph Watson, David M. Miller, III, Dept. of Cell and Developmental Biology,
Vanderbilt University Med. Ctr., Nashville, TN
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Check out my Profile! Isolation of chemotaxis defective mutants with altered str-1 expression levels using automated, high-sensitivity fluorescence Profiling, #12
Anthony A. Ferrante1, Britta Moellers1, Jennifer Kean1, Gregory O'Connor1, Vance Chang1, Bruce Holcombe1,
Peter Van Osta2, Steven Alam1 1) Union Biometrica, Inc., 35 Medford St, Holliston, MA 01746, 2) Union Biometrica, GMBH, Cipalstraat 3, B-2440, Geel, Belgium
• View Abstract
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The 14th Biennial C. elegans Conference, June 29-July 3, 2003
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Imaging strategies and data types for genome-wide comparison and pattern-matching of GFP expression patterns: GLO-Worm, Program #41.
William A. Mohler. Genetics and Dev. Bio., UConn Health Center, Farmington USA.
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Isolation of Long-Lived Individuals Within an Isogenic Population, Program # 145.
Shane L. Rea, Deqing Wu, Abigail Smith, Thomas E. Johnson. Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO USA.
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Anti-fungal innate immune defence in C. elegans, Program #287.
Carole Couillault1, Nathalie Pujol1, Laurence Sabatier2, Jean-Fran?ois Guichou3, Yuji Kohara4,
Jonathan Ewbank1. 1) CIML, Marseille, France; 2) IBMC, Strasbourg, France; 3) CBS, Montpellier, France; 4) NIG, Mishima, Japan.
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GFP screens for regulators of motor neuron differentiation, Program #520A.
Joseph D. Watson, David M. Miller. Neuroscience Program Cell and Developmental Biology, Vanderbilt University, Nashville, TN USA.
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Applications of the COPAS (Complex Object Parametric Analysis and Sorting) Biosort to functional genomic studies, Program #1111A.
Judith S. Gordon, Nigel J. O'Neil, Patricia E. Kuwabara. The Wellcome Trust Sanger Institute, Cambridge, UK.
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Mos1 mutagenesis and the Union Biometrica worm sorter: complementary tools for a genetic screen for worms that resist bacterial infection, Program #314B.
Anne Millet, Jonathan Ewbank. CIML, Marseille, FRANCE.
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A high throughput screening method to detect youthful nematodes, Program #356B.
Peter J. Schmeissner, Suzhen Guo, Laura A. Herndon, Monica Driscoll. Molecular Biology and Biochem, Rutgers University, Piscataway, NJ USA.
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Measurement and analysis of stress induced responses in transgenic Caenorhabditis elegans, Program #389B.
Rock Pulak, Britta Moellers, Julia Thompson. Union Biometrica, Holliston, MA USA.
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Developing an automating worm-based screen for bacterial virulence factors using the Union Biometrica sorter, Program #312C.
C. Lèopold Kurz, Aurèlie Blanc, Elizabeth Pradel, Jonathan Ewbank. CIML, Marseille, FRANCE.
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Genetic analysis of IFT and ARPKD: Isolating osm-5 suppressors, Program #510C.
Renee L. Engle1, Hongmin Qin2, Joel Rosenbaum2, Maureen M. Barr3. 1) Laboratory of Genetics,
University of Wisconsin, Madison, WI USA; 2) Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT USA;
3) School of Pharmacy, University of Wisconsin, Madison, WI, USA.
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American Society of Cell Biology 42nd Annual Meeting, December 14-18, 2002
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Measurement and analysis of stress induced responses in transgenic Caenorhabditis elegans, #L340.
R. Pulak, J. Thompson, B. Moellers; Life Sciences, Union Biometrica, Inc., Holliston, MA
• View Abstract
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West Coast C. elegans Meeting, August 10 - 13, 2002
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GFP screens for regulators of motor neuron differentiation, #242.
Joseph Watson, David M. Miller, III, Dept. of Cell and Developmental Biology,
Vanderbilt University Med. Ctr., Nashville, TN
• View Abstract
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Check out my Profile! Isolation of chemotaxis defective mutants with altered str-1 expression levels using automated, high-sensitivity fluorescence Profiling, #12
Anthony A. Ferrante1, Britta Moellers1, Jennifer Kean1, Gregory O'Connor1, Vance Chang1, Bruce Holcombe1,
Peter Van Osta2, Steven Alam1 1) Union Biometrica, Inc., 35 Medford St, Holliston, MA 01746, 2) Union Biometrica, GMBH, Cipalstraat 3, B-2440, Geel, Belgium
• View Abstract
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Microscience 2002, London, July 9-11, 2002
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The application of scale space and the spatial color model in microscopy.
P. Van Osta, Union Biometrica N.V., European Scientific Operations;
Additional authors: K. Ver Donck*, J.M. Geusebroek**, L. Bols*, J.Geysen*, B.M. ter; Haar Romeny***
*Union Biometrica N.V., European Scientific Operations, Geel, Belgium. ** ISIS, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands
*** TU Eindhoven, Faculty Biomedical Technology, Biomedical Imageprocessing, Den Dolech, Eindhoven, the Netherlands
• View Abstract (PDF)
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The Multi-Mode Mosaic framework for automated microscopy and analysis.
P. Van Osta, Union Biometrica N.V., European Scientific Operations, Additional authors: K. Ver Donck*, J.M. Geusebroek**, L. Bols*, J.Geysen*
*Union Biometrica N.V., European Scientific Operations,
** ISIS, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands
• View Abstract (PDF)
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Midwest Worm Meeting, June 28-30, 2002
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Suppressors of gon-1, #626415
Dan Hesselson1, Judith Kimble2, 3,
1) Department of Genetics, University of Wisconsin-Madison, Madison, WI
2) Department of Biochemistry, University of Wisconsin-Madison, Madison, WI
3) Howard Hughes Medical Institute, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI
• View Abstract
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Isolation of chemotaxis defective mutants with altered str-1 expression levels using automated, high-sensitivity fluorescence profiling, #496373.
Anthony A. Ferrante, Britta Moellers, Jennifer Kean, Gregory O'Connor, Vance Chang, Bruce Holcombe, Steve Alam, Peter Van Osta. Union Biometrica, Inc., Holliston, MA
• View Abstract
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Joint Microscopy Meeting, Lille, France, June 24-28, 2002
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Application of linear scale space and the spatial color model in microscopy,
P. Van Osta*, K. Ver Donck*, L. Bols*, J.Geysen*, J.M. Geusebroek**, B.M. ter Haar Romeny***,
* Union Biometrica N.V., European Scientific Operations, Cipalstraat 3, B-2440 Geel, Belgium,
** Intelligent Sensory Information Systems, Faculty of Science, UvA, Amsterdam, The Netherlands,
*** BioMedische Technologie, Technische Universiteit Eindhoven, Eindhoven, The Netherlands
• View Abstract (PDF)
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2002 East Coast Worm Meeting, June 14-16, 2002
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Post-embryonic Developmental Expression Chronograms: a new functional genomics data type generated using a nematode fluorescence sorting system, #178.
William A. Mohler1, Rock Pulak2, Anthony Ferrante2,
1) University of Connecticut Health Center, Farmington CT, 2) Union Biometrica, Holliston MA
• View Abstract
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Check out my Profile! Isolation of mutants with altered str-1 expression levels using automated, high-sensitivity fluorescence profiling, #112.
Anthony A. Ferrante, Britta Moellers, Vance Chang, Bruce Holcombe, Steve Alam, Union Biometrica, Inc., Holliston, MA
• View Abstract
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Multi-parameter & Dual Color Fluorescence Analysis and Flow Sorting of C. elegans, #199.
Rock Pulak, Jen Kean, Britta Moellers, Union Biometrica, Inc., Holliston, MA
• View Abstract
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European Worm Meeting, May 18-21, 2002
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Enhanced Analytical Performance of the C. elegans Flow Sorter COPAS BIOSORT: Automated Re-analysis of
Populations in Multi-well Plates and Reading of Axially Distributed Positional Fluorescent Signals, #32.
Johan Geysen*, Steve Alam, Anthony Ferrante, Peter Kalutkewitz, Peter Van Osta*, Susan Zusman,
Union Biometrica Inc. & European Scientific Operations(*)
• View Abstract
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Enhanced One-step Nematode Recognition on micrographs of Living C. elegans Cultures in 384-well Plates using Linear Scale Space Mathematics.
Peter Van Osta*, Kris Ver Donck*, Jan-Mark Geusebroek**, Luc Bols* and Johan Geysen*
*Union Biometrica, European Scientific Operations, Geel, Belgium;
**Intelligent Sensory Information Systems, UvA, Amsterdam, the Netherlands.
• View Abstract
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Multi-parametric & dual color fluorescent analysis and flow sorting of C. elegans.
Rico Bongaarts*, Luc Bols*, Johan Geysen*, Anthony Ferrante**, Brian Dell'Orfano**, Susan Zusman**
*Union Biometrica, European Scientific Operations, Geel, Belgium; **Union Biometrica, Holliston, MA, USA.
• View Abstract
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2001 International Worm Meeting, June 22-26, 2001
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Fully Automated Instrumentation for Analysis in C elegans, #1089.
Rock Pulak, Peter Kalutkiewicz, Anthony Ferrante, Greg O'Connor, Jennifer Kean, Ralph Clover, Union Biometrica, Inc., Holliston, MA
• View Abstract
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Application of the COPAS (Complex Object Parametric Analysis and Sorting) dispenser to functional genomic studies, #1096.
GL Bell, NJ O'Neil, A Coulson, PE Kuwabara, The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
• View Abstract
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Automated Sorting of C. elegans Muv Mutants According to Pseudovulva Number, #1097.
Anthony A. Ferrante, Peter Kalutkiewicz, Steve Alam, Russell Gershman, W. Peter Hansen, Union Biometrica, Inc., Holliston, MA
• View Abstract
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2000 East Coast Worm Meeting, June 9-11, 2000
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Boy Is My Bursa Red: Automated Detection and Sorting of Fluorescent Stained C. elegans Males From a Mixed Population, #89.
A Ferrante, L Thibodeau, G O'Connor, WP Hansen, Union Biometrica, Inc. (Holliston, MA).
• View Abstract
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1999 International Worm Meeting, June 2 - 6, 1999
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Adapting a manual clonal screen to semi-automation, #858.
BT Tsung1, AA Ferrante2, WP Hansen2, PB Krauledat2, C Johnson3, CP Hunter1, 1) MCB, Harvard University, Cambridge,
MA, 02138., 2) Union Biometrica, 19 Ward St., Holliston, MA 01746, 3) Axys, Nemapharm Group, South San Francisco, CA
• View Abstract
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Automated sorting and dispensing of C. elegans to wells of microtiter plates, #443.
CD Johnson1, R Clover1, B Reardon1, PB Krauledat2, AA Ferrante2, WP Hansen2. 1)Axys Pharmaceuticals, NemaPharm Group, South San Francisco,
CA, 2)Union Biometrica, Inc., Holliston, MA.
• View Abstract
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C = conference presentation
P = peer reviewed publication
A = printed periodical article
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